Patterns of Non-injection Drug Use Associated with Injection Cessation among Street-Involved Youth in Vancouver, Canada

Although abstinence from drug use is often a key goal of youth substance use treatment, transitioning to less harmful routes and types of drug use is desirable from both a clinical and public health perspective. Despite this, little is known about the trajectories of youth who inject drugs including changes in patterns of non-injection drug use. The At-Risk Youth Study (ARYS) is a longitudinal cohort of street-involved youth who use drugs in Vancouver, Canada. We used linear growth curve modeling to compare changes in non-injection drug use among participants who ceased injecting drugs for at least one 6-month period between September 2005 and May 2015 to matched controls who continued injecting over the same period. Of 387 eligible participants, 173 (44.7%) reported ceasing drug injection at least once. Non-injection drug use occurred during 160 (79.6%) periods of injection cessation. In adjusted linear growth curve analyses, the only non-injection drug use pattern observed to decrease significantly more than controls following injection cessation was daily crack/cocaine use (p = 0.024). With the exception of frequent crack/cocaine use, transitions out of injection drug use did not appear to coincide with increased reductions in patterns of non-injection drug use. Our findings indicate that most (80%) of the observed injection cessation events occurred in the context of ongoing substance use. Given that transitioning out of drug injection represents a significant reduction in risk and harm, efforts supporting vulnerable youth to move away from injecting may benefit from approaches that allow for ongoing non-injection drug use. &nbsp

New paleomagnetic data from Late Neoproterozoic sedimentary successions in Southern Urals, Russia: implications for the Late Neoproterozoic paleogeography of the Iapetan realm

We present the results of paleomagnetic study of Ediacaran sedimentary successions from the Southern Urals. The analysis of the sedimentary rocks of the Krivaya Luka, Kurgashlya and Bakeevo Formations reveal stable mid-temperature and high-temperature remanence components.Mid-temperature components were acquired during Devonian (Bakeevo Formation) and Late Carboniferous–Early Permian remagnetization events. The high-temperature components in Kurgashlya and Bakeevo Formations are interpreted to be primar , because they are supported by a positive conglomerate test (Bakeevo Formation) and magnetostratigraphic pattern (Kurgashlya Formation). Thehigh-temperature component in the Krivaya Luka Formation is interpreted to be a Late Ediacaran overprint. Our new paleomagnetic poles together with some previously published Ediacaran poles from Baltica and Laurentia are used herein to produce a series of paleogeographic reconstructions of the opening of the Iapetus Ocean